A Review: Highlighting the Links between Epigenetics, COVID-19 Infection, and Vitamin D.

ABSTRACT: The highly transmittable and infectious COVID-19 remains a major threat worldwide, with the elderly and comorbid individuals being the most vulnerable. While vaccines are currently available, therapeutic drugs will help ease the viral outbreak and prevent serious health outcomes. Epigenetic modifications regulate gene expression through changes in chromatin structure and have been linked to viral pathophysiology. Since epigenetic modifications contribute to the life cycle of the virus and host immune responses to infection, epigenetic drugs are promising treatment targets to ameliorate COVID-19. Deficiency of the multifunctional secosteroid hormone vitamin D is a global health threat. Vitamin D and its receptor function to regulate genes involved in immunity, apoptosis, proliferation, diff

SUBMITTER: Foolchand A 

PROVIDER: S-EPMC9603374 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature