Low Diversity and Instability of the Sinus Microbiota over Time in Adults with Cystic Fibrosis.

ABSTRACT: Chronic rhinosinusitis (CRS) is a common, yet underreported and understudied manifestation of upper respiratory disease in people with cystic fibrosis (CF). Recently developed standard of care guidelines for the management of CF CRS suggest treatment of upper airway disease may ameliorate lower airway disease. We sought to determine whether changes to sinus microbial community diversity and specific taxa known to cause CF lung disease are associated with increased respiratory disease and inflammation. We performed 16S rRNA gene sequencing, supplemented with cytokine analyses, microscopy, and bacterial culturing, on samples from the sinuses of 27 adults with CF CRS. At each study visit, participants underwent endoscopic paranasal sinus sampling and clinical evaluation. We identified key dri

SUBMITTER: Armbruster CR 

PROVIDER: S-EPMC9603634 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature