Genetic Diversity of Fowlpox Virus and Putative Genes Involved in Its Pathogenicity.

ABSTRACT: To determine the genomic variations of fowlpox virus (FPV)-the largest, very ancient, and still harmful avian virus-the complete genomes of 21 FPVs were analyzed. The genomes showed low genetic diversity relative to their overall size. Our studies revealed that FPVs could phylogenetically be divided into two clades, based on their regional distribution, and comparative analysis showed that 40 putative proteins of FPV were associated with geographic differences in viruses, viral pathogenicity, or the onset of diphtheritic lesions. The strain, classified into a subgroup different from others in the genomic analysis, showed relatively low pathogenicity in chickens, and the onset of diphtheritic lesions was observed to be caused only by the specific strain. Despite genetic differences, some co

SUBMITTER: Kim HR 

PROVIDER: S-EPMC9603804 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature