Genome-Wide Analysis Reveals that PhoP Regulates Pathogenicity in Riemerella anatipestifer.

ABSTRACT: Duck infectious serositis, also known as Riemerella anatipestifer disease, infects domestic ducks, geese, and turkeys and wild birds. However, the regulatory mechanism of its pathogenicity remains unclear. The PhoPR two-component system (TCS) was first reported in Gram-negative bacteria in our previous research and was demonstrated to be involved in virulence and gene expression. Here, DNA affinity purification sequencing (DAP-seq) was applied to further explore the regulation of PhoPR in relation to pathogenicity in R. anatipestifer. A conserved motif was identified upstream of 583 candidate target genes which were directly regulated by PhoP. To further confirm the genes which are regulated by PhoR and PhoP, single-gene-deletion strains were constructed. The results of transcriptome analy

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC9603813 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature