Oxidative stress alters transcript localization of disease-associated genes in the retinal pigment epithelium.

ABSTRACT:

Purpose

Nuclear retention is a mechanism whereby excess RNA transcripts are stored in the event that a cell needs to quickly respond to a stimulus; maintaining proper nuclear-to-cytoplasmic balance is important for cellular homeostasis and cell function. There are many mechanisms that are employed to determine whether to retain a transcript or export it to the cytoplasm, although the extent to which tissue or cell type, internal and external stressors, and disease pathogenesis affect this process is not yet clear. As the most biochemically active tissue in the body, the retina must mitigate endogenous and exogenous stressors to maintain cell health and tissue function. Oxidative stress, believed to contribute to the pathogenesis or progression of age-related macular degeneration (A

SUBMITTER: Kaczynski TJ 

PROVIDER: S-EPMC9603899 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature