Similarities of P1-Like Phage Plasmids and Their Role in the Dissemination of bla_CTX-M-55.

ABSTRACT: The P1-like phage plasmid (PP) has been widely used as a molecular biology tool, but its role as an active accessory cargo element is not fully understood. In this study, we provide insights into the structural features and gene content similarities of 77 P1-like PPs in the RefSeq database. We also describe a P1-like PP carrying a bla_CTX-M-55 gene, JL22, which was isolated from a clinical strain of Escherichia coli from a duck farm. P1-like PPs were very similar and conserved based on gene content similarities, with only eight highly variable regions. Importantly, two kinds of replicon types, namely, IncY and p0111, were identified and can be used to specifically identify the P1-like phage. JL22 is similar to P1, acquiring an important foreign DNA fragment with two obviou

SUBMITTER: Wang M 

PROVIDER: S-EPMC9603915 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature