Ubiquitin Proteasome Gene Signatures in Ependymoma Molecular Subtypes.

ABSTRACT: The ubiquitin proteasome system (UPS) is critically important for cellular homeostasis and affects virtually all key functions in normal and neoplastic cells. Currently, a comprehensive review of the role of the UPS in ependymoma (EPN) brain tumors is lacking but may provide valuable new information on cellular networks specific to different EPN subtypes and reveal future therapeutic targets. We have reviewed publicly available EPN gene transcription datasets encoding components of the UPS pathway. Reactome analysis of these data revealed genes and pathways that were able to distinguish different EPN subtypes with high significance. We identified differential transcription of several genes encoding ubiquitin E2 conjugases associated with EPN subtypes. The expression of the E2 conjugase gen

SUBMITTER: Vriend J 

PROVIDER: S-EPMC9604155 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature