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A Perspective on the (Rise and Fall of) Protein β-Turns.


ABSTRACT: The β-turn is the third defined secondary structure after the α-helix and the β-sheet. The β-turns were described more than 50 years ago and account for more than 20% of protein residues. Nonetheless, they are often overlooked or even misunderstood. This poor knowledge of these local protein conformations is due to various factors, causes that I discuss here. For example, confusion still exists about the assignment of these local protein structures, their overlaps with other structures, the potential absence of a stabilizing hydrogen bond, the numerous types of β-turns and the software's difficulty in assigning or visualizing them. I also propose some ideas to potentially/partially remedy this and present why β-turns can still be helpful, even in the AlphaFold 2 era.

SUBMITTER: de Brevern AG 

PROVIDER: S-EPMC9604201 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature

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A Perspective on the (Rise and Fall of) Protein β-Turns.

de Brevern Alexandre G AG  

International journal of molecular sciences 20221014 20


The β-turn is the third defined secondary structure after the α-helix and the β-sheet. The β-turns were described more than 50 years ago and account for more than 20% of protein residues. Nonetheless, they are often overlooked or even misunderstood. This poor knowledge of these local protein conformations is due to various factors, causes that I discuss here. For example, confusion still exists about the assignment of these local protein structures, their overlaps with other structures, the pote  ...[more]

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