Mitochondria-Targeting Polymer Micelles in Stepwise Response Releasing Gemcitabine and Destroying the Mitochondria and Nucleus for Combined Antitumor Chemotherapy.

ABSTRACT: Mitochondrial DNA and nuclear DNA are essential genetic material which play an important role in maintaining normal metabolism, survival, and proliferation of cells. Constructing a mitochondria-targeting stimuli-responsive nano-drug delivery system releasing chemotherapeutic agents in a stepwise response manner and destroying mitochondrial DNA and nuclear DNA simultaneously is an effective way to improve the anti-tumor effect of chemotherapeutic agents. In this study, a new mitochondria-targeting pH/ROS dual-responsive block copolymer TPP-PEG2k-b-(BS-AA)_n (P1), untargeted pH/ROS dual-responsive copolymer mPEG2k-b-(BS-AA)_n (P2), pH single-responsive copolymer (mPEG2k-b-(AH-AA)_n (P3), ROS single-responsive copolymer mPEG2k-b-(SA-TG

SUBMITTER: Zhang S 

PROVIDER: S-EPMC9604266 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature