Filamentous Hemagglutinin of Bordetella pertussis Does Not Interact with the β₂ Integrin CD11b/CD18.

ABSTRACT: The pertussis agent Bordetella pertussis produces a number of virulence factors, of which the filamentous hemagglutinin (FhaB) plays a role in B. pertussis adhesion to epithelial and phagocytic cells. Moreover, FhaB was recently found to play a crucial role in nasal cavity infection and B. pertussis transmission to new hosts. The 367 kDa FhaB protein translocates through an FhaC pore to the outer bacterial surface and is eventually processed to a ~220 kDa N-terminal FHA fragment by the SphB1 protease. A fraction of the mature FHA then remains associated with bacterial cell surface, while most of FHA is shed into the bacterial environment. Previously reported indirect evidence suggested that FHA, or its precursor FhaB, may bind the β₂ integrin CD11b/CD18 of h

SUBMITTER: Golshani M 

PROVIDER: S-EPMC9604300 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature