Molecular Mechanisms of RSV and Air Pollution Interaction: A Scoping Review.

ABSTRACT: RSV is one of the major infectious agents in paediatrics, and its relationship with air pollution is frequently observed. However, the molecular basis of this interaction is sparsely reported. We sought to systematically review the existing body of literature and identify the knowledge gaps to answer the question: which molecular mechanisms are implied in the air pollutants-RSV interaction? Online databases were searched for original studies published before August 2022 focusing on molecular mechanisms of the interaction. The studies were charted and a narrative synthesis was based upon three expected directions of influence: a facilitated viral entry, an altered viral replication, and an inappropriate host reaction. We identified 25 studies published between 1993 and 2020 (without a notic

SUBMITTER: Wrotek A 

PROVIDER: S-EPMC9604398 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature