Dissecting Polygenic Etiology of Ischemic Stroke in the Era of Precision Medicine.

ABSTRACT: Ischemic stroke (IS), the leading cause of death and disability worldwide, is caused by many modifiable and non-modifiable risk factors. This complex disease is also known for its multiple etiologies with moderate heritability. Polygenic risk scores (PRSs), which have been used to establish a common genetic basis for IS, may contribute to IS risk stratification for disease/outcome prediction and personalized management. Statistical modeling and machine learning algorithms have contributed significantly to this field. For instance, multiple algorithms have been successfully applied to PRS construction and integration of genetic and non-genetic features for outcome prediction to aid in risk stratification for personalized management and prevention measures. PRS derived from variants with eff

SUBMITTER: Li J 

PROVIDER: S-EPMC9604604 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature