Access to Anti-Biofilm Compounds from Endolichenic Fungi Using a Bioguided Networking Screening.

ABSTRACT: Endolichenic microorganisms represent a new source of bioactive natural compounds. Lichens, resulting from a symbiotic association between algae or cyanobacteria and fungi, constitute an original ecological niche for these microorganisms. Endolichenic fungi inhabiting inside the lichen thallus have been isolated and characterized. By cultivation on three different culture media, endolichenic fungi gave rise to a wide diversity of bioactive metabolites. A total of 38 extracts were screened for their anti-maturation effect on Candida albicans biofilms. The 10 most active ones, inducing at least 50% inhibition, were tested against 24 h preformed biofilms of C. albicans, using a reference strain and clinical isolates. The global molecular network was associated to bioactivity dat

SUBMITTER: Toure S 

PROVIDER: S-EPMC9604612 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature