Modulations of local synchrony over time lead to resting-state functional connectivity in a parsimonious large-scale brain model.

ABSTRACT: Biophysical models of large-scale brain activity are a fundamental tool for understanding the mechanisms underlying the patterns observed with neuroimaging. These models combine a macroscopic description of the within- and between-ensemble dynamics of neurons within a single architecture. A challenge for these models is accounting for modulations of within-ensemble synchrony over time. Such modulations in local synchrony are fundamental for modeling behavioral tasks and resting-state activity. Another challenge comes from the difficulty in parametrizing large scale brain models which hinders researching principles related with between-ensembles differences. Here we derive a parsimonious large scale brain model that can describe fluctuations of local synchrony. Crucially, we do not reduce w

SUBMITTER: Portoles O 

PROVIDER: S-EPMC9604991 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature