Resistance of Bacteria toward 475 nm Blue Light Exposure and the Possible Role of the SOS Response.

ABSTRACT: The increase in antibiotic resistance represents a major global challenge for our health systems and calls for alternative treatment options, such as antimicrobial light-based therapies. Blue light has shown promising results regarding the inactivation of a variety of microorganisms; however, most often, antimicrobial blue light (aBL) therapy is performed using wavelengths close to the UV range. Here we investigated whether inactivation was possible using blue light with a wavelength of 475 nm. Both Gram-positive and -negative bacterial strains were treated with blue light with fluences of 7.5-45 J/cm². Interestingly, only some bacterial strains were susceptible to 475 nm blue light, which was associated with the lack of RecA, i.e., a fully functional DNA repair mechanism. We de

SUBMITTER: Metzger M 

PROVIDER: S-EPMC9605056 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature