Integrative QTL mapping and selection signatures in Groningen White Headed cattle inferred from whole-genome sequences.

ABSTRACT: Here, we aimed to identify and characterize genomic regions that differ between Groningen White Headed (GWH) breed and other cattle, and in particular to identify candidate genes associated with coat color and/or eye-protective phenotypes. Firstly, whole genome sequences of 170 animals from eight breeds were used to evaluate the genetic structure of the GWH in relation to other cattle breeds by carrying out principal components and model-based clustering analyses. Secondly, the candidate genomic regions were identified by integrating the findings from: a) a genome-wide association study using GWH, other white headed breeds (Hereford and Simmental), and breeds with a non-white headed phenotype (Dutch Friesian, Deep Red, Meuse-Rhine-Yssel, Dutch Belted, and Holstein Friesian); b) scans for s

SUBMITTER: Gonzalez-Prendes R 

PROVIDER: S-EPMC9605288 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature