Effects of gonadal steroids on reward circuitry function and anhedonia in women with a history of postpartum depression.

ABSTRACT:

Background

Reward system dysfunction is evident across neuropsychiatric conditions. Here we present data from a double-blinded pharmaco-fMRI study investigating the triggering of anhedonia and reward circuit activity in women.

Methods

The hormonal states of pregnancy and parturition were simulated in euthymic women with a history of postpartum depression (PPD+; n = 15) and those without such a history (PPD-; n = 15) by inducing hypogonadism, adding back estradiol and progesterone for 8 weeks ("addback"), and then withdrawing both steroids ("withdrawal"). Anhedonia was assessed using the Inventory of Depression and Anxiety Symptoms (IDAS) during each hormone phase. Those who reported a 30 % or greater increase in IDAS anhedonia, dysphoria, or ill temper during addback or with

SUBMITTER: Schiller CE 

PROVIDER: S-EPMC9605402 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature