Caspofungin Affects Extracellular Vesicle Production and Cargo in Candida auris.

ABSTRACT: Antifungal resistance has become more frequent, either due to the emergence of naturally resistant species or the development of mechanisms that lead to resistance in previously susceptible species. Among these fungal species of global threat, Candida auris stands out for commonly being highly resistant to antifungal drugs, and some isolates are pan-resistant. The rate of mortality linked to C. auris infections varies from 28% to 78%. In this study, we characterized C. auris extracellular vesicles (EVs) in the presence of caspofungin, an echinocandin, which is the recommended first line antifungal for the treatment of infections due to this emerging pathogen. Furthermore, we also analyzed the protein and RNA content of EVs generated by C. auris cultivated with o

SUBMITTER: Amatuzzi RF 

PROVIDER: S-EPMC9605528 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature