Identification of Universally Applicable and Species-Specific Marker Peptides for Bacillus anthracis.

ABSTRACT: Anthrax is a zoonotic infection caused by the bacterium Bacillus anthracis (BA). Specific identification of this pathogen often relies on targeting genes located on two extrachromosomal plasmids, which represent the major pathogenicity factors of BA. However, more recent findings show that these plasmids have also been found in other closely related Bacillus species. In this study, we investigated the possibility of identifying species-specific and universally applicable marker peptides for BA. For this purpose, we applied a high-resolution mass spectrometry-based approach for 42 BA isolates. Along with the genomic sequencing data and by developing a bioinformatics data evaluation pipeline, which uses a database containing most of the publicly available protein sequences worl

SUBMITTER: Witt N 

PROVIDER: S-EPMC9605612 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature