Agreement Between Measures of Adherence to Isoniazid Preventive Therapy Among People With HIV in Uganda.

ABSTRACT:

Background

Isoniazid (INH) preventative therapy is recommended for people with HIV (PWH) in resource-constrained settings. Valid measures are needed to assess adherence. We aimed to examine agreement between measures overall and by level of social desirability.

Methods

PWH with latent tuberculosis (TB) were recruited in Mbarara, Uganda. Past 30-day adherence was measured by the number of days with pill bottle openings using a medication event monitoring system (MEMS) and self-reported number of days pills taken. INH concentration (INH plus acetyl INH and their ratio) in hair samples was measured. We used Bland-Altman plots to examine agreement between adherence measures and calculated the area under the receiver operating characteristics curve (AUROC) to determine if INH hai

SUBMITTER: Forman LS 

PROVIDER: S-EPMC9605696 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature