Ventral hippocampus-lateral septum circuitry promotes foraging-related memory.

ABSTRACT: Remembering the location of a food or water source is essential for survival. Here, we reveal that spatial memory for food location is reflected in ventral hippocampus (HPCv) neuron activity and is impaired by HPCv lesion. HPCv mediation of foraging-related memory involves communication to the lateral septum (LS), as either reversible or chronic disconnection of HPCv-to-LS signaling impairs spatial memory retention for food or water location. This neural pathway selectively encodes appetitive spatial memory, as HPCv-LS disconnection does not affect spatial memory for escape location in a negative reinforcement procedure, food intake, or social and olfactory-based appetitive learning. Neural pathway tracing and functional mapping analyses reveal that LS neurons recruited during the appetiti

SUBMITTER: Decarie-Spain L 

PROVIDER: S-EPMC9605732 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature