Novel Coagulation Test Detects Anticoagulation Resistance and Is Associated With Thrombotic Events in Pediatric Patients Requiring Extracorporeal Membrane Oxygenation.

ABSTRACT: Bivalirudin, an IV direct thrombin inhibitor, and unfractionated heparin (UFH) are frequently used anticoagulants in the pediatric critical care setting. An accurate, specific, point-of-care test to quantify and detect anticoagulation resistance is not currently available. This study evaluates the ability of a rapid (< 10 min), micro-volume (< 50 uL) coagulation test to detect and quantify the anticoagulation effect of bivalirudin and UFH using a functional, clot time endpoint in pediatric critical care patients.

Design

Single-site retrospective laboratory sample analysis and chart review.

Setting

A 105-bed pediatric and cardiac ICUs delivering extracorporeal membrane oxygenation.

Subjects

Forty-one citrated, frozen, biobanked plasma specimens comprising 21 with

SUBMITTER: Frydman GH 

PROVIDER: S-EPMC9605743 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature