Neurocognitive functioning in children with sickle cell anemia and history of abnormal transcranial doppler ultrasonography.

ABSTRACT:

Background

Transcranial doppler (TCD) ultrasonography can be used to identify stroke risk in children with sickle cell anemia. Previous studies have reported mixed findings on neurocognitive outcomes in children with elevated TCD. This study examined associations between TCD velocity and neurocognitive outcomes in children and adolescents without prior history of stroke.

Procedure

Participants were selected from the Sickle Cell Clinical Research Intervention Program cohort. The highest recorded mean maximum TCD velocity was selected for analysis, along with participant's most recent data from serial neurocognitive surveillance.

Results

A total of 200 children with sickle cell anemia completed neurocognitive testing (109 males, 91 females; mean age 12.7 years [SD = 3.5

SUBMITTER: Longoria JN 

PROVIDER: S-EPMC9605768 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature