Novel antigen-presenting cell imparts T_reg-dependent tolerance to gut microbiota.

ABSTRACT: Establishing and maintaining tolerance to self-antigens or innocuous foreign antigens is vital for the preservation of organismal health. Within the thymus, medullary thymic epithelial cells (mTECs) expressing autoimmune regulator (AIRE) have a critical role in self-tolerance through deletion of autoreactive T cells and promotion of thymic regulatory T (T_reg) cell development^1-4. Within weeks of birth, a separate wave of T_reg cell differentiation occurs in the periphery upon exposure to antigens derived from the diet and commensal microbiota^5-8, yet the cell types responsible for the generation of peripheral T_reg (pT_reg) cells have not been identified. Here we describe the identification of a class of RORγt⁺ antig

SUBMITTER: Akagbosu B 

PROVIDER: S-EPMC9605865 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature