Intraprocedural MRI-based dosimetry during transarterial radioembolization of liver tumours with holmium-166 microspheres (EMERITUS-1): a phase I trial towards adaptive, image-controlled treatment delivery.

ABSTRACT:

Purpose

Transarterial radioembolization (TARE) is a treatment for liver tumours based on injection of radioactive microspheres in the hepatic arterial system. It is crucial to achieve a maximum tumour dose for an optimal treatment response, while minimizing healthy liver dose to prevent toxicity. There is, however, no intraprocedural feedback on the dose distribution, as nuclear imaging can only be performed after treatment. As holmium-166 (¹⁶⁶Ho) microspheres can be quantified with MRI, we investigate the feasibility and safety of performing ¹⁶⁶Ho TARE within an MRI scanner and explore the potential of intraprocedural MRI-based dosimetry.

Methods

Six patients were treated with ¹⁶⁶Ho TARE in a hybrid operating room. Per injection position, a

SUBMITTER: Roosen J 

PROVIDER: S-EPMC9606012 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature