Novel Antidepressant-Like Properties of the Iron Chelator Deferiprone in a Mouse Model of Depression.

ABSTRACT: Depressed individuals who carry the short allele for the serotonin-transporter-linked promotor region of the gene are more vulnerable to stress and have reduced response to first-line antidepressants such as selective serotonin reuptake inhibitors. Since depression severity has been reported to correlate with brain iron levels, the present study aimed to characterise the potential antidepressant properties of the iron chelator deferiprone. Using the serotonin transporter knock-out (5-HTT KO) mouse model, we assessed the behavioural effects of acute deferiprone on the Porsolt swim test (PST) and novelty-suppressed feeding test (NSFT). Brain and blood iron levels were also measured following acute deferiprone. To determine the relevant brain regions activated by deferiprone, we then measured

SUBMITTER: Uzungil V 

PROVIDER: S-EPMC9606181 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature