Identification of cuproptosis-related lncRNA prognostic signature for osteosarcoma.

ABSTRACT:

Background

Copper is an indispensably mineral element involved in various metabolic processes and functions in the active sites of many metalloproteins. Copper dysregulation is associated with cancers such as osteosarcoma (OS), the most common primary bone malignancy with invasiveness and metastasis. However, the causality between cuproptosis and OS remains elusive. We aim to identify cuproptosis-related long non-coding RNAs (lncRNAs) for osteosarcomatous prognosis, immune microenvironment response, and immunotherapy.

Methods

The Person correlation and differential expression analysis were used to identify differentially expressed cuproptosis-related lncRNAs (CRLs). The univariate, least absolute shrinkage and selection operator (LASSO), and multivariate Cox regression analy

SUBMITTER: Liu B 

PROVIDER: S-EPMC9606239 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature