Allelic diversity of the pharmacogene CYP2D6 in New Zealand Maori and Pacific peoples.

ABSTRACT: The enzyme cytochrome P450 2D6 (CYP2D6) metabolises approximately 25% of commonly prescribed drugs, including analgesics, anti-hypertensives, and anti-depressants, among many others. Genetic variation in drug metabolising genes can alter how an individual responds to prescribed drugs, including predisposing to adverse drug reactions. The majority of research on the CYP2D6 gene has been carried out in European and East Asian populations, with many Indigenous and minority populations, such as those from Oceania, greatly underrepresented. However, genetic variation is often population specific and analysis of diverse ethnic groups can reveal differences in alleles that may be of clinical significance. For this reason, we set out to examine the range and frequency of CYP2D6 varia

SUBMITTER: Hitchman LM 

PROVIDER: S-EPMC9606245 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature