In vitro and ex vivo anti-myeloma effects of nanocomposite As₄S₄/ZnS/Fe₃O₄.

ABSTRACT: Nanoparticles in medicine can integrate actively targeted imaging agents and drug delivery vehicles, and combining multiple types of therapeutics in a single particle has numerous advantages, especially in multiple myeloma. MM is an incurable hematological disorder characterized by clonal proliferation of plasma cells in the bone marrow. In this study, we evaluated the anti-myeloma activity of 3 nanocomposites (3NPs): As₄S₄/ZnS/Fe₃O₄ (1:4:1), As₄S₄/ZnS/Fe₃O₄ with folic acid (FA), and As₄S₄/ZnS/Fe₃O₄ with FA and albumin with reduced survival MM cell lines and primary MM samples by each of 3NP. Cytotoxic effects of 3NPs were associated with caspase- and mitochon

SUBMITTER: Cholujova D 

PROVIDER: S-EPMC9606304 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature