¹⁸F-DCFPyL PET/CT in advanced high-grade epithelial ovarian cancer: A prospective pilot study.

ABSTRACT:

Objectives

Glutamate carboxypeptidase-II (GCP-II), a zinc metalloenzyme that resides in cell membrane, has been reported as overexpressed in the neovasculature of ovarian cancers. The study objective was to determine whether GCP-II targeted imaging with ¹⁸F-DCFPyL PET/CT can detect disease sites in women with advanced high-grade serous ovarian cancer (HGSOC).

Materials and methods

Twenty treatment-naïve women with advanced HGSOC were recruited (median age 60 years). Prior to commencing therapy (primary cytoreductive surgery [n=9] or neoadjuvant chemotherapy [n=11]), subjects underwent routine staging with contrast-enhanced abdominopelvic CT (=CT), followed by ¹⁸F-DCFPyL PET/CT (=PET). CT and PET were reported independently using a standardized reporting

SUBMITTER: Metser U 

PROVIDER: S-EPMC9606351 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature