KnockoffTrio: A knockoff framework for the identification of putative causal variants in genome-wide association studies with trio design.

ABSTRACT: Family-based designs can eliminate confounding due to population substructure and can distinguish direct from indirect genetic effects, but these designs are underpowered due to limited sample sizes. Here, we propose KnockoffTrio, a statistical method to identify putative causal genetic variants for father-mother-child trio design built upon a recently developed knockoff framework in statistics. KnockoffTrio controls the false discovery rate (FDR) in the presence of arbitrary correlations among tests and is less conservative and thus more powerful than the conventional methods that control the family-wise error rate via Bonferroni correction. Furthermore, KnockoffTrio is not restricted to family-based association tests and can be used in conjunction with more powerful, potentially nonlinea

SUBMITTER: Yang Y 

PROVIDER: S-EPMC9606389 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature