Effect of antibiotics in the first week of life on faecal microbiota development.

ABSTRACT:

Background

Infants are frequently exposed to antibiotics (AB) in the first week of life for suspected bacterial infections. Little is known about the effect of AB on the developing intestinal microbiota. Therefore, we studied intestinal microbiota development with and without AB exposure in the first week of life in term born infants.

Methods

We analysed the faecal microbiota from birth until 2.5 years of age by 16S rRNA gene amplicon sequencing in a cohort with 56 term born infants, exposed to AB in the first week of life (AB+) (AB for 2-3 days (AB2, n=20), AB for 7 days (AB7, n=36)), compared with 126 healthy controls (AB-). The effects of AB and duration were examined in relation to delivery and feeding mode.

Results

AB+ was associated with significantly increased

SUBMITTER: Van Daele E 

PROVIDER: S-EPMC9606546 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature