A more novel and powerful prognostic gene signature of lung adenocarcinoma determined from the immune cell infiltration landscape.

ABSTRACT:

Background

Lung adenocarcinoma (LUAD) is the leading histological subtype of lung cancer worldwide, causing high mortality each year. The tumor immune cell infiltration (ICI) is closely associated with clinical outcome with LUAD patients. The present study was designed to construct a gene signature based on the ICI of LUAD to predict prognosis.

Methods

Downloaded the raw data of three cohorts of the TCGA-LUAD, GSE72094, and GSE68465 and treat them as training cohort, validation cohort one, and validation cohort two for this research. Unsupervised clustering detailed grouped LUAD cases of the training cohort based on the ICI profile. The univariate Cox regression and Kaplan-Meier was adopted to identify potential prognostic genes from the differentially expressed genes recogn

SUBMITTER: Ma C 

PROVIDER: S-EPMC9606711 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature