Non-invasive measurement of tumor immune microenvironment and prediction of survival and chemotherapeutic benefits from ¹⁸F fluorodeoxyglucose PET/CT images in gastric cancer.

ABSTRACT:

Background

The tumor immune microenvironment could provide prognostic and predictive information. It is necessary to develop a noninvasive radiomics-based biomarker of a previously validated tumor immune microenvironment signature of gastric cancer (GC) with immunohistochemistry staining.

Methods

A total of 230 patients (training (n = 153) or validation (n = 77) cohort) with gastric cancer were subjected to (Positron Emission Tomography-Computed Tomography) radiomics feature extraction (80 features). A radiomics tumor immune microenvironment score (RTIMS) was developed to predict the tumor immune microenvironment signature with LASSO logistic regression. Furthermore, we evaluated its relation with prognosis and chemotherapy benefits.

Results

A 8-feature radiomics sign

SUBMITTER: Li J 

PROVIDER: S-EPMC9606753 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature