Ontology highlight
ABSTRACT:
SUBMITTER: Fakhry MM
PROVIDER: S-EPMC9607164 | biostudies-literature | 2022 Oct
REPOSITORIES: biostudies-literature
Fakhry Mariam M MM Mahmoud Kazem K Nafie Mohamed S MS Noor Ahmad O AO Hareeri Rawan H RH Salama Ismail I Kishk Safaa M SM
Pharmaceuticals (Basel, Switzerland) 20221010 10
Breast cancer is a disease in which cells in the breast divide continuously without control. There are great limitations in cancer chemotherapy. Hence, it is essential to search for new cancer therapeutics. Herein, a novel series of EGFR/HER2 dual inhibitors has been designed based on the hybridization of thiazole and pyrazoline fragments. The synthesized compounds were screened for their anti-proliferative activity against MCF-7 breast cancer cell line and MCF-10 normal breast cell line. Intere ...[more]