Interactions between Medications and the Gut Microbiome in Inflammatory Bowel Disease.

ABSTRACT: In view of the increasing evidence that commonly prescribed, non-antibiotic drugs interact with the gut microbiome, we re-examined the microbiota variance in inflammatory bowel disease (IBD) to determine the degree to which medication and supplement intake might account for compositional differences between disease subtypes and geographic location. We assessed the confounding effects of various treatments on the faecal microbiota composition (16S rRNA gene sequencing) in persons with Crohn's disease (CD; n = 188) or ulcerative colitis (UC; n = 161) from either Cork (Ireland) or Manitoba (Canada) sampled at three time points. The medication profiles between persons with UC and CD and from different countries varied in number and type of drugs taken. Among Canadian participants with CD, surg

SUBMITTER: Eckenberger J 

PROVIDER: S-EPMC9607329 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature