Topographical and Compositional Gradient Tubular Scaffold for Bone to Tendon Interface Regeneration.

ABSTRACT: The enthesis is an extremely specific region, localized at the tendon-bone interface (TBI) and made of a hybrid connection of fibrocartilage with minerals. The direct type of enthesis tissue is commonly subjected to full laceration, due to the stiffness gradient between the soft tissues and hard bone, and this often reoccurs after surgical reconstruction. For this purpose, the present work aimed to design and develop a tubular scaffold based on pullulan (PU) and chitosan (CH) and intended to enhance enthesis repair. The scaffold was designed with a topographical gradient of nanofibers, from random to aligned, and hydroxyapatite (HAP) nanoparticles along the tubular length. In particular, one part of the tubular scaffold was characterized by a structure similar to bone hard tissue, with a r

SUBMITTER: Bianchi E 

PROVIDER: S-EPMC9607365 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature