The Japanese Encephalitis Antigenic Complex Viruses: From Structure to Immunity.

ABSTRACT: In the last three decades, several flaviviruses of concern that belong to different antigenic groups have expanded geographically. This has resulted in the presence of often more than one virus from a single antigenic group in some areas, while in Europe, Africa and Australia, additionally, multiple viruses belonging to the Japanese encephalitis (JE) serogroup co-circulate. Morphological heterogeneity of flaviviruses dictates antibody recognition and affects virus neutralization, which influences infection control. The latter is further impacted by sequential infections involving diverse flaviviruses co-circulating within a region and their cross-reactivity. The ensuing complex molecular virus-host interplay leads to either cross-protection or disease enhancement; however, the molecular de

SUBMITTER: Khare B 

PROVIDER: S-EPMC9607441 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature