Neutrophils as emerging protagonists and targets in chronic inflammatory diseases.

ABSTRACT:

Introduction

Neutrophils are the key cells of our innate immune system with a primary role in host defense. They rapidly arrive at the site of infection and display a range of effector functions including phagocytosis, degranulation, and NETosis to eliminate the invading pathogens. However, in recent years, studies focusing on neutrophil biology have revealed the highly adaptable nature and versatile functions of these cells which extend beyond host defense. Neutrophils are now referred to as powerful mediators of chronic inflammation. In several chronic inflammatory diseases, their untoward actions, such as immense infiltration, hyper-activation, dysregulation of effector functions, and extended survival, eventually contribute to disease pathogenesis. Therefore, a better understan

SUBMITTER: Rawat K 

PROVIDER: S-EPMC9607713 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature