Compliance with Prescribing and Dispensing Conditions for Valproate and Related Substances in Girls and Women of Childbearing Potential: A Survey of Community Pharmacists in France.

ABSTRACT:

Introduction

Prenatal exposure to valproate and related substances is associated with a risk of malformations and/or neurodevelopmental disorders. In France, prescription and dispensing conditions of oral valproate forms are subject to risk minimization measures for girls and women of childbearing potential with the aim to limit pregnancy under this treatment. These risk minimization measures were issued in 2015 and were strengthened in 2018.

Objective

We aimed to evaluate compliance with prescription and dispensing conditions of valproate for oral administration: an annual prescription from a specialist and a signed risk acknowledgment form.

Methods

Two prospective observational surveys were carried out between 2018 and 2020 on a representative sample of French commu

SUBMITTER: Fauvelle K 

PROVIDER: S-EPMC9607717 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature