Association Between Selective Decontamination of the Digestive Tract and In-Hospital Mortality in Intensive Care Unit Patients Receiving Mechanical Ventilation: A Systematic Review and Meta-analysis.

ABSTRACT:

Importance

The effectiveness of selective decontamination of the digestive tract (SDD) in critically ill adults receiving mechanical ventilation is uncertain.

Objective

To determine whether SDD is associated with reduced risk of death in adults receiving mechanical ventilation in intensive care units (ICUs) compared with standard care.

Data sources

The primary search was conducted using MEDLINE, EMBASE, and CENTRAL databases until September 2022.

Study selection

Randomized clinical trials including adults receiving mechanical ventilation in the ICU comparing SDD vs standard care or placebo.

Data extraction and synthesis

Data extraction and risk of bias assessments were performed in duplicate. The primary analysis was conducted using a bayesian framework.

SUBMITTER: Hammond NE 

PROVIDER: S-EPMC9607997 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature