Renal mTORC1 activation is associated with disease activity and prognosis in lupus nephritis.

ABSTRACT:

Objective

This study was initiated to evaluate mammalian target of rapamycin (mTOR) activation in renal tissue of LN patients.

Methods

This retrospective study included 187 LN patients, 20 diabetic nephropathy (DN) patients, 10 minimal change disease (MCD) patients and 10 normal controls (NCs). Seven of 187 LN patients had repeated renal biopsies. mTORC1/2 activation was evaluated by immunohistochemistry and multiplexed immunofluorescence. The association of mTORC1/2 activation with the clinicopathologic indices and prognostic outcomes was analysed among 187 LN patients. Proteomics was performed in renal biopsies of 20 LN patients. Proteomics was employed to comprehensively evaluate the impact of mTOR activation on intrarenal gene expression.

Results

mTORC1/2 was sign

SUBMITTER: Mao Z 

PROVIDER: S-EPMC9608003 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature