New management approaches to tuberculosis in people living with HIV.

ABSTRACT:

Purpose of review

People living with HIV (PLWH) are commonly coinfected with Mycobacterium tuberculosis, particularly in high-transmission resource-limited regions. Despite expanded access to antiretroviral therapy and tuberculosis (TB) treatment, TB remains the leading cause of death among PLWH. This review discusses recent advances in the management of TB in PLWH and examines emerging therapeutic approaches to improve outcomes of HIV-associated TB.

Recent findings

Three recent key developments have transformed the management of HIV-associated TB. First, the scaling-up of rapid point-of-care urine-based tests for screening and diagnosis of TB in PLWH has facilitated early case detection and treatment. Second, increasing the availability of potent new and repurposed drugs to

SUBMITTER: Mhango DV 

PROVIDER: S-EPMC9608335 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature