Increased Serum Levels of miR-125b and miR-132 in Fragile X Syndrome: A Preliminary Study.

ABSTRACT:

Background and objectives

Fragile X syndrome (FXS) is a neurodevelopmental disorder, identified as the most common cause of hereditary intellectual disability and monogenic cause of autism spectrum disorders (ASDs), caused by the loss of fragile X mental retardation protein (FMRP). FMRP is an RNA-binding protein, a regulator of translation that plays an important role in neurodevelopment, and its loss causes cognitive and behavioral deficits. MicroRNAs (miRNAs) are small molecules that regulate gene expression in diverse biological processes. Previous studies found that the interaction of FMRP with miR-125b and miR-132 regulates the maturation and synaptic plasticity in animal models and miRNA dysregulation plays a role in the pathophysiology of FXS. The present study aimed to anal

SUBMITTER: Couto RR 

PROVIDER: S-EPMC9608387 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature