Rapid recurrence in head and neck cancer: Underappreciated problem with poor outcome.

ABSTRACT:

Background

Rapid recurrence, defined as gross tumor recurrence after primary operation but prior to initiating postoperative radiation therapy (PORT), is underappreciated in head and neck cancer (HNC).

Methods

CT simulation images in patients with HNC managed surgically with adjuvant therapy at a single center between 2010 and 2017 were retrospectively reviewed.

Results

A total of 194 patients with HNC were included. Rapid recurrence occurred in 39 patients (20%) with a median time from operation to CT simulation of 37 days. On multivariable analysis (MVA), extranodal extension (ENE) was the only predictor of rapid recurrence (P = .03). While rapid recurrence, ENE, and perineural invasion were all associated with poor overall survival (OS) on MVA, rapid recurrence was

SUBMITTER: Lee DY 

PROVIDER: S-EPMC9608429 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature