Resveratrol Analogues as Selective Estrogen Signaling Pathway Modulators: Structure-Activity Relationship.

ABSTRACT: Resveratrol is a plant-derived phytoalexin found in grapes, red wine and many other plants used in Asian folk medicine. It is extensively studied for pleiotropic biological activity. The most crucial are anticancer and chemopreventive properties. Resveratrol has also been reported to be an antioxidant and phytoestrogen. The phytoestrogenic activity of resveratrol was assayed in different in vitro and in vivo models. Although these works brought some, on the first look, conflicting results, it is commonly accepted that resveratrol interacts with estrogen receptors and functions as a mixed agonist/antagonist. It is widely accepted that the hydroxyl groups are crucial for resveratrol's cytotoxic and antioxidative activity and are responsible for binding estrogen receptors. In this work, we as

SUBMITTER: Kobylka P 

PROVIDER: S-EPMC9608462 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature