Adaptive Functioning in Children and Adolescents With Sickle Cell Disease.

ABSTRACT:

Objective

Risk for neurocognitive deficits in sickle cell disease (SCD) is well established, yet minimal research has evaluated the risk for deficits in adaptive functioning. We assessed adaptive functioning in pediatric patients with SCD to test the hypothesis that disease, treatment, and demographic factors were associated with adaptive outcomes.

Methods

Two hundred fifty-six patients (57% HbSS/HbSß0-thalassemia and 43% HbSC/HbSß+-thalassemia), ages 8-18, received routine neuropsychological assessments as part of a larger prospective lifetime cohort study. Adaptive functioning was measured using the Behavior Assessment System for Children, Second or Third Edition. Adaptive scores were compared with normative values using t-test or Wilcoxon signed rank test and linear regre

SUBMITTER: Trpchevska A 

PROVIDER: S-EPMC9608581 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature