Pre- and postsynaptic alterations in the visual cortex of the P23H-1 retinal degeneration rat model.

ABSTRACT: P23H rats express a variant of rhodopsin with a mutation that leads to loss of visual function with similar properties as human autosomal dominant retinitis pigmentosa (RP). The advances made in different therapeutic strategies to recover visual system functionality reveal the need to know whether progressive retina degeneration affects the visual cortex structure. Here we are interested in detecting cortical alterations in young rats with moderate retinal degeneration, and in adulthood when degeneration is severer. For this purpose, we studied the synaptic architecture of the primary visual cortex (V1) by analyzing a series of pre- and postsynaptic elements related to excitatory glutamatergic transmission. Visual cortices from control Sprague Dawley (SD) and P23H rats at postnatal days 30

SUBMITTER: Martinez-Galan JR 

PROVIDER: S-EPMC9608761 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature