Biochemical characterization of a cyanobactin arginine-N-prenylase from the autumnalamide biosynthetic pathway.
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ABSTRACT:
SUBMITTER: Clemente C
PROVIDER: S-EPMC9609003 | biostudies-literature | 2022 Oct
REPOSITORIES: biostudies-literature
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Biochemical characterization of a cyanobactin arginine-<i>N</i>-prenylase from the autumnalamide biosynthetic pathway.
Clemente Claudia C Johnson Nicholas N Ouyang Xiaodan X Popin Rafael V RV Dall'Angelo Sergio S Wahlsten Matti M Jokela Jouni J Colombano Alessandro A Nardone Brunello B Fewer David P DP Houssen Wael E WE
Chemical communications (Cambridge, England) 20221027 86
Cyanobactins are linear and cyclic post-translationally modified peptides. Here we show that the prenyl-D-Arg-containing autumnalamide A is a member of the cyanobactin family. Biochemical assays demonstrate that the AutF prenyltransferase targets the guanidinium moiety in arginine and homoarginine and is a useful tool for biotechnological applications. ...[more]
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