Biochemical characterization of a cyanobactin arginine-N-prenylase from the autumnalamide biosynthetic pathway.

ABSTRACT: Cyanobactins are linear and cyclic post-translationally modified peptides. Here we show that the prenyl-D-Arg-containing autumnalamide A is a member of the cyanobactin family. Biochemical assays demonstrate that the AutF prenyltransferase targets the guanidinium moiety in arginine and homoarginine and is a useful tool for biotechnological applications.

SUBMITTER: Clemente C 

PROVIDER: S-EPMC9609003 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature