Early corticosteroid dose tapering in patients with acute exacerbation of idiopathic pulmonary fibrosis.

ABSTRACT:

Background

Although corticosteroid therapy with dose tapering is the most commonly used treatment for acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF), there is no consensus on the tapering regimen. This study aimed to investigate the association between early corticosteroid dose tapering and in-hospital mortality in patients with AE-IPF.

Methods

In this retrospective cohort study, we analyzed the data of a cohort from eight Japanese tertiary care hospitals and routinely collected administrative data from a cohort from 185 Japanese hospitals. Patients with AE-IPF were classified into the early and non-early tapering groups depending on whether the maintenance dose of corticosteroids was reduced within two weeks of admission. Propensity score analysis with inverse

SUBMITTER: Anan K 

PROVIDER: S-EPMC9609246 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature